The Drive to Discover. The Experience to Deliver.

Careers At Incyte Corporation

Looking for a challenge and a chance to grow your career?

Then Incyte is the pharmaceutical company for you. While our pipeline demonstrates the ability to compete with much larger pharmaceutical companies in selecting compelling targets and creating high-quality drug candidates, our smaller size enables employees to see the direct impact of their contributions on the direction of the company. Due to our smart, agile culture and cutting-edge science, we delivered a novel, first-to-market product in an unmet medical need in 2011 - the first in the company's history.

Opportunities for taking on new and/or additional responsibilities, in addition to advancement, are a key element in our culture. Add to that a science-based, fast-paced work environment and you’ve got an exciting company in which to work.

In addition to opportunities for growth, we offer an outstanding benefits andcompensation package to help meet personal needs as well.

Take a look at our current openings to find the match that’s right for you!

Incyte Corporation values the talents of our diverse workforce and is proud to be an Equal Opportunity Employer.

Principal Investigator, Pharmacology

Department: Preclinical Pharmacology
Location: Incyte Corporate Headquarters

Incyte is a biopharmaceutical company focused on the discovery, development, and commercialization of novel medicines to meet serious unmet medical needs in oncology and inflammation and autoimmunity. Incyte is committed to the rigorous pursuit of research and development excellence to improve the lives of patients, make a difference in health care, and build sustainable value. 

The Company strives to discover and develop first-in-class and best-in-class medicines-advancing a diverse portfolio of large and small molecules.

We are seeking a motivated individual to join our In Vivo Small Molecule Pharmacology group.  This scientist will provide expertise and leadership for in vivo pharmacology studies that will aid in the discovery and advancement of novel tumor-directed and immuno-oncology based therapeutics.  A successful candidate will be able to work independently to direct and conduct in vivo experiments in appropriate syngeneic, xenograft, PDX and humanized models.  Incyte’s culture of scientific rigor necessitates a candidate with a current and broad command of cancer biology and a willingness to work as part of cross-functional teams.  Although this individual will be working to characterize the utility of novel agents, the candidate will also be expected to contribute to efforts with a number of established agents in our pipeline and selection of new targets.

Essential Functions of the Job (Key responsibilities)

  • Design or develop the appropriate in vivo model systems to answer key biological or pharmacological questions. This includes execution of antitumor efficacy studies, and studies to understand PK/PD relationships and drug mechanism of action.
  • Perform ex vivo assessments of drug activity (e.g. Western blotting, MSD, HTRF, ELISA, flow cytometry)
  • Demonstrate the ability to contribute to multiple projects, and collaborate with stakeholders from all relevant functions
  • Research potential new drug targets and present to management for consideration as new drug discovery programs
  • Manage energetic and enthusiastic bench scientists

Qualifications (Minimal acceptable level of education, work experience, and competency)

  • Ph.D. in Immunology, Cancer Biology, Pharmacology or related field
  • Minimum of 5 years of Pharma/Biotech experience
  • Experience with in vivo models of cancer
  • Experience with handling and dosing of mice (i.v., i.p, s.c. and oral)
  • Strong knowledge of cancer biology
  • Expertise in a variety of ex-vivo assays; expertise in multi-color flow cytometry is a plus
  • Excellent communication skills and a strong publication record
  • Prior experience managing bench scientists

Disclaimer:  The above statements are intended to describe the general nature and level of work performed by employees assigned to this job. They are not intended to be an exhaustive list of all duties, responsibilities, and qualifications.   Management reserves the right to change or modify such duties as required.


Incyte Corporation is committed to creating a diverse environment and is proud to be an equal opportunity employer.

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