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Careers At Incyte Corporation

Looking for a challenge and a chance to grow your career?

Then Incyte is the pharmaceutical company for you. While our pipeline demonstrates the ability to compete with much larger pharmaceutical companies in selecting compelling targets and creating high-quality drug candidates, our smaller size enables employees to see the direct impact of their contributions on the direction of the company. Due to our smart, agile culture and cutting-edge science, we delivered a novel, first-to-market product in an unmet medical need in 2011 - the first in the company's history.

Opportunities for taking on new and/or additional responsibilities, in addition to advancement, are a key element in our culture. Add to that a science-based, fast-paced work environment and you’ve got an exciting company in which to work.

In addition to opportunities for growth, we offer an outstanding benefits andcompensation package to help meet personal needs as well.

Take a look at our current openings to find the match that’s right for you!

Incyte Corporation values the talents of our diverse workforce and is proud to be an Equal Opportunity Employer.

Senior / Exec Director, Preclinical Pharmacology

Department: Preclinical Pharmacology
Location: Incyte Corporate Headquarters

Job Summary

This position will report directly to the Vice President, Small Molecule Discovery Biology and Preclinical Pharmacology and will serve as a member of the senior preclinical pharmacology leadership team. This individual will be part of the small molecule discovery preclinical pharmacology department within the Incyte Research Institute, a world-class organization of nearly 300 scientists dedicated to the discovery and advancement of novel therapeutic approaches to revolutionize the treatment of cancer.

The Preclinical Pharmacology organization is currently comprised of ~65 highly talented drug discovery scientists that have built one of the most robust and innovative pipelines in the biopharmaceutical industry, with 15 small molecules currently in or entering clinical development.

Key Responsibilities: 

  • leadership and oversight of approximately 50% of our in vivo pharmacology team (@11 Ph.D and BS/MS level scientists) providing small molecule program support, primarily in the area of tumor-directed therapy;
  • program level leadership for multiple preclinical research efforts as well as Incyte’s GVHD activities;
  • leadership of Incyte’s new target identification effort (integration of multidimensional cancer genomics and functional data to build a robust early portfolio; 
  • oversight of academic research efforts, with specific Joint Steering Committee leadership responsibilities;
  • Maintain an excellent grasp on emerging areas of cancer research and new therapeutic targets;  
  • Ensure generation of high quality data to support decision making on individual compounds and programs and effectively communicates the data to senior leadership; 
  • advocate early development strategy, biomarker selection, and combination approaches for new development programs;  
  • maintain strategic focus across multiple complex drug discovery projects in prioritizing resource allocation to drive decisions consistent with the corporate goals;
  • effectively collaborate with other functions in the discovery and clinical departments

Qualifications (Minimal acceptable level of education, work experience, and competency)  

  • PhD in biological sciences including molecular/cell biology, pharmacology, or biochemistry with focus on oncology 
  • 10+ years of experience in an academic and/or industry setting
  • extensive experience with in vivo cancer models, including tumor xenograft models, primary tumor models, and syngeneic and genetically-engineered mouse models with an in depth, state of the art working knowledge of using these models to establish pharmacokinetic/pharmacodynamic relationships and assessing anti-tumor efficacy of pharmacological agents 
  • Competency in cancer genomics, target mining/validation and 3D/in-vivo functional screens 
  • Experience in managing/leading external collaborations with both academic and industry partners 
  • proven track record of publications in high impact areas of oncology
  • prior experience managing a team of scientists

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