The Drive to Discover. The Experience to Deliver.

Careers At Incyte Corporation

Looking for a challenge and a chance to grow your career?

Then Incyte is the pharmaceutical company for you. While our pipeline demonstrates the ability to compete with much larger pharmaceutical companies in selecting compelling targets and creating high-quality drug candidates, our smaller size enables employees to see the direct impact of their contributions on the direction of the company. Due to our smart, agile culture and cutting-edge science, we delivered a novel, first-to-market product in an unmet medical need in 2011 - the first in the company's history.

Opportunities for taking on new and/or additional responsibilities, in addition to advancement, are a key element in our culture. Add to that a science-based, fast-paced work environment and you’ve got an exciting company in which to work.

In addition to opportunities for growth, we offer an outstanding benefits andcompensation package to help meet personal needs as well.

Take a look at our current openings to find the match that’s right for you!

Incyte Corporation values the talents of our diverse workforce and is proud to be an Equal Opportunity Employer.

Research Investigator, Cell Line Development

Department: Global BioPharma Dev
Location: Incyte Corporate Headquarters

Incyte is a biopharmaceutical company focused on the discovery, development, and commercialization of novel medicines to meet serious unmet medical needs in oncology and inflammation and autoimmunity. Incyte is committed to the rigorous pursuit of research and development excellence to improve the lives of patients, make a difference in health care, and build sustainable value. 

The Company strives to discover and develop first-in-class and best-in-class medicines-advancing a diverse portfolio of large and small molecules.

Our Global BioPharmaceutical Development Group is looking for a Research Investigator, Cell Line Development.  This position develops commercially viable cell lines that are used in the production of therapeutic recombinant proteins such as fusion protein, monoclonal and bispecific antibodies.

Key responsibilities:

  • Perform transfection, routine cell culture work, including cell passage and secure freeze.
  • Operate amber15 for Fed-batch study.
  • Evaluate CHO host and vector technologies of in-house licensed and new CRO technologies to establish platform for mAb production.
  • Design and execute high throughput assays to screen mAb or BsAb minipools and clones, ensure production, product quality.
  • Design and conduct genetic stability of cell lines.
  • Qualify single cell plating and imaging workflow to ensure that monoclonality assessments meet regulatory expectations.
  • Perform clone genetic stability study.
  • Oversee the creation and maintenance of research cell banks as well as Master and Working Cell Banks manufactured and tested at Contract Labs.
  • Present data summaries and study conclusions at internal scientific meetings.
  • Train junior staff scientist.
  • Ensure all work is appropriately documented in electronic lab notebook and reports are written in timely manner.


  • Doctoral degree with 2-5 years relevant experience and/or Masters’ degree with 5-10 years relevant experience and/or Bachelors’ degree in Biopharmaceuticals plus 10 years’ relevant experience in molecular or cell biology, chemical engineering, or related field.
  • Prefer at least 3 years’ experience in developing high titer CHO cell lines expressing recombinant proteins such as fusion protein, monoclonal antibody, bispecific antibody.
  • Experience with molecular biology, such as Vector construction, Restriction. digestion/purification plasmids, extraction of gDNA or RNA from CHO cells.
  • Experience with Vector NTI, and Sequencher software.
  • Experience with high throughput techniques in 384 and/or 96 well plate format such as Octet, ELISA, Guava, SDS-PAGE, ProA Spin-Column purification etc.
  • Experience with statistical Design of Experiment is a plus.
  • Strong written and verbal communication and organization skills are required.

Disclaimer:  The above statements are intended to describe the general nature and level of work performed by employees assigned to this job. They are not intended to be an exhaustive list of all duties, responsibilities, and qualifications.   Management reserves the right to change or modify such duties as required.

Incyte Corporation is committed to creating a diverse environment and is proud to be an equal opportunity employer.

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