The Drive to Discover. The Experience to Deliver.

Careers At Incyte Corporation

Looking for a challenge and a chance to grow your career?

Then Incyte is the pharmaceutical company for you. While our pipeline demonstrates the ability to compete with much larger pharmaceutical companies in selecting compelling targets and creating high-quality drug candidates, our smaller size enables employees to see the direct impact of their contributions on the direction of the company. Due to our smart, agile culture and cutting-edge science, we delivered a novel, first-to-market product in an unmet medical need in 2011 - the first in the company's history.

Opportunities for taking on new and/or additional responsibilities, in addition to advancement, are a key element in our culture. Add to that a science-based, fast-paced work environment and you’ve got an exciting company in which to work.

In addition to opportunities for growth, we offer an outstanding benefits andcompensation package to help meet personal needs as well.

Take a look at our current openings to find the match that’s right for you!

Incyte Corporation values the talents of our diverse workforce and is proud to be an Equal Opportunity Employer.


Principal Investigator / Associate Director, DMPK

Department: DMB
Location: Incyte Corporate Headquarters

Incyte is a biopharmaceutical company focused on the discovery, development, and commercialization of novel medicines to meet serious unmet medical needs in oncology and inflammation and autoimmunity. Incyte is committed to the rigorous pursuit of research and development excellence to improve the lives of patients, make a difference in health care, and build sustainable value. 

The Company strives to discover and develop first-in-class and best-in-class medicines-advancing a diverse portfolio of large and small molecules.

Job Summary  (Primary function)

Our DMPK group is seeking a highly motivated and well accomplished DMPK project lead to provide strategic DMPK support to the discovery and nonclinical development of small molecule and biologics drugs. The selected individual will be an integral project team member representing DMPK on small molecule and biologics research projects to ensure effective integration of ADME, PK and PKPD into the team strategy.

Job Responsibilities:  

  • Serve as a DMPK project lead on discovery and development project teams. Initiate and engage in multifunctional collaborations to facilitate the advancement of drug candidates and build thorough knowledge of drug candidate properties.
  • Be responsible for the design and interpretation of DMPK studies necessary for the selection of clinical candidates.  
  • Ensure adequate characterization and liability assessment to support candidate nomination and clinical dose projections.  
  • Responsible for writing PK and TK reports, and author DMPK sections for regulatory submissions and IB updates.
  • Develop interdisciplinary collaborations and ensure that key DMPK data, information, and priorities are integrated into overall project team strategy.

Minimum Requirements 

  • PhD or equivalent with 5+ years of industry experience in DMPK
  • A strong working knowledge of pharmacokinetics with hands on experience using PK software packages is required. Knowledge and expertise in modeling such as PBPK and PK/PD is a desirable plus. PK knowledge and experience on biologics is a plus.
  • A broad knowledge of drug-drug interactions, metabolizing enzymes, clearance mechanisms, absorption, transporters, and bioanalytical techniques is required
  • Experience as a DMPK project lead in discovery programs is desirable.
  • Appropriate understanding of applicable FDA and European regulations with experience in IND filing and clinical protocols is a plus
  • Excellent oral and written communication skills are essential along with strong organizational skills.

Disclaimer:  The above statements are intended to describe the general nature and level of work performed by employees assigned to this job. They are not intended to be an exhaustive list of all duties, responsibilities, and qualifications.   Management reserves the right to change or modify such duties as required.

Incyte Corporation is committed to creating a diverse environment and is proud to be an equal opportunity employer.

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